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Lab
Lab
The science behind the magic
WHAT WE DO

Signum Biosciences is a private biotech company founded in 2003 from technologies developed by Dr. Jeffry Stock at Princeton University. With over 15 years of developing multiple ingredients and botanical extracts from discovery to fully formulated skin-care products that are on the market, Signum possesses the ability to streamline your research and product development.

We specialize in producing customized claim support and dermatological efficacy testing to provide clients with robust scientific data needed to substantiate product claims and/or compare head to head versus competitors. We work with clients ranging from multi-national companies to virtual biotech startups, all projects are welcomed. We have highly trained scientists who can tailor a research plan to fit your requirements be it efficacy, safety, regulatory or scientific marketing. Whether you are early in discovery phase, development, clinical stage, or ready to commercialize your products, Signum can provide the following services to aid you on your product development path.

  • Standard assays to determine activity profile
  • Safety and regulatory support
  • Customized screening
  • Topical formulation development, stability and dermal penetration studies
  • Scientific marketing and peer-reviewed publishing of results
  • Botanical extraction, characterization and manufacturing
  • Compound synthesis and manufacturing

Signum is the solution to optimize your R&D screening, product development and customized research at a reduced cost compared to larger CRO’s. We provide superior service to differentiate your product, so contact us today. Our discussions will provide the scientific excellence and quality your product deserves.

"I have been using Epicutis for about a month and it has transformed my dry, sun-damaged skin. My skin feels and looks so much more youthful and healthy." - Katy
STANDARD ASSAYS
Catalog # Model Stimulus/Inducer Endpoint Method  Reference
SKI-001 Human Epidermal Keratinocytes (NHEKs) or Human Reconstructed Epidermis (EpiDerm™) TPA/PMA Chemical irritation Cytokine ELISA Glucocorticoid
SKI-002 UVB Photodamage
SKI-003 Sunburn Cells Vitamin C
SKI-004 DNA pyrimidine dimers
SKI-005 Lipid Peroxides
SKI-006 Peripheral Blood Mononuclear Cells (PBMC) anti-CD3/CD28 T-cell activation Th2/Th17-marker ELISA TGF-beta
SKI-007 Human Dermal Microvascular Endothelial Cells (HDMECs) ATP-gS ATP inflammation MTS Viability, Cytokine ELISA Glucocorticoid
SKI-008 anti-microbial peptide (LL-37) Cathelicidin
SKI-009 Nickel sulfate Nickel Allergy
SKI-010 Human Epidermal Keratinocytes (NHEKs) C. acnes, PGN IL-8 Dexamethasone
SKI-011 Human Reconstructed Cornea (EpiOcular™) Dry Eye Viability, MMP9
Dr. Stock and his son Maxwell Stock founded Signum Biosciences Inc., a biotechnology company spun out of Princeton University, whose focus is to develop novel ingredients for both the cosmetic and pharmaceutical space.
By continuing to modify small molecules in order to yield skin benefitting effects, TSC was created. Its ability to repair skin, lower inflammation and many other skin health promoting properties makes it a unique ingredient without comparison
Signum’s corporate partner Rohto Pharmaceutical’s top formulator Masanori Tamura is the developer of Japan’s #1 moisturizer line Hada Labo. Tamura’s high-quality formulation efforts at Rohto attracted to the Signum Team’s attention while he was working in the US. After collaborating, Tamura joined the Signum team as our head formulator and director of Product Development.
Our development of botanical extracts began as an interest in the foods we know to be therapeutic. By studying foods that humans already crave and consume we can make assumptions on why these foods are sought after. Chia seeds are exceptionally powerful and when put through our patented extraction process, yields a novel, proprietary topical oil that improves skin hydration and barrier function unlike any other on the market.
After 20 years of dermatology focused R&D, Epicutis™ is launched using unique, patented ingredients in simple formulations. We have created two products to help maintain skin health rather than trying to address the surface level symptoms of our skin.
After 20 years of dermatology focused R&D, Epicutis™ is launched using unique, patented ingredients in simple formulations. We have created two products to help maintain skin health rather than trying to address the surface level symptoms of our skin.