The science behind the magic

Signum Biosciences is a private biotech company founded in 2003 from technologies developed by Dr. Jeffry Stock at Princeton University. With over 15 years of developing multiple ingredients and botanical extracts from discovery to fully formulated skin-care products that are on the market, Signum possesses the ability to streamline your research and product development.

We specialize in producing customized claim support and dermatological efficacy testing to provide clients with robust scientific data needed to substantiate product claims and/or compare head to head versus competitors. We work with clients ranging from multi-national companies to virtual biotech startups, all projects are welcomed. We have highly trained scientists who can tailor a research plan to fit your requirements be it efficacy, safety, regulatory or scientific marketing. Whether you are early in discovery phase, development, clinical stage, or ready to commercialize your products, Signum can provide the following services to aid you on your product development path.

  • Standard assays to determine activity profile
  • Safety and regulatory support
  • Customized screening
  • Topical formulation development, stability and dermal penetration studies
  • Scientific marketing and peer-reviewed publishing of results
  • Botanical extraction, characterization and manufacturing
  • Compound synthesis and manufacturing

Signum is the solution to optimize your R&D screening, product development and customized research at a reduced cost compared to larger CRO’s. We provide superior service to differentiate your product, so contact us today. Our discussions will provide the scientific excellence and quality your product deserves.

"I have been using Epicutis for about a month and it has transformed my dry, sun-damaged skin. My skin feels and looks so much more youthful and healthy." - Katy

I have been using Epicutis for about a month and it has transformed my dry, sun-damaged skin. My skin feels and looks so much more youthful and healthy.



I love the packaging because I have total control over how much I use and I can see when I am almost out.




My introduction to Epicutis was from Lauretta at Scottsdale Ridge Medi Spa. I use medical grade products always and switched to using Epicutis each morning and evening. I was very happy to notice a deeper sense of moisturized skin. My skin took on a dewy and bright look with no makeup on. Any soft lines I had seemed to fade away with the amount of moisture my skin retained.. The ease of using 2 products only to accomplish this was a pleasant surprise. I highly recommend this luxurious 2 step plan to glowing skin!





Epicutis is seriously the most amazing product that I have ever used. The results are instantaneous but the long term results are what has blown me away. I haven’t worn foundation for over 3 months and I am someone who before Epicutis would not leave the house without it! Thank you Signum for creating something simple that truly works.





I love how the serum feels on my skin because it soaks in immediately, especially after I shave. My skin never feels greasy after I put the products on or shiny yet it feels very smooth and hydrated. I also appreciate the product being scent free.






I love Epicutis. My skin has never been more bright and clear. I love how soft it feels when I put it on and more importantly how easy it is to use. The product is simple to use, clean and so effective! I’m hooked!




I have been using Epicutis for 3 months now and can’t live without it! I am not easily impressed with skin care products and feel I have tried everything over the years. I live in a dry environment and Epicutis keeps my skin looking hydrated and healthy. My adult acne has disappeared as well. That has never happened before. Absolutely love it!!





In my forties, taking care of my skin became a top focus, and I loved the high level skin care line I used. But, it wasn’t working as well after a few years…

Then I discovered Epicutis through a local MedSpa. Game changer! My skin transformed with fine lines fading, varying tones became more even, and the best part for me was that my skin could hold hydration. I have always had a problem with dry, flakey patches and now they are gone completely! I’m in love! Thank you, Epicutis!






I absolutely love the Epicutis Skincare. I started using it twice a day and eliminated all of my other product lines, my face has never looked better even when I was young! My skin is literally glowing!! I am so happy that you shared this product with me. It’s unreal gorgeous and I couldn’t be happier




As a licensed Aesthetician I’ve had the opportunity to use a lot of great skincare. products. So far, Epicutis is #1 on my list. I have sensitive skin and many products irritate my skin. But not Epicutis. I’ve noticed better hydration, and a more even skin tone. The tinted spf I use goes on effortlessly, no pilling of products. I’m happy to recommend this product to all skin types and conditions. My clients are seeing improvements too, so that makes my job easier!





This is the best face cream I have ever used! I suffered from a detergent allergy that went un-detected for almost 2 years and my face was a wreck. Since I started Epicutis, I have noticed the scaring on my face has lessened, the tone and texture is smooth and the residual hyperpigmentation for the blemishing is almost nonexistent. I have very sensitive skin and am always reluctant to try new products. I can honestly say, I found my skincare for life!





I am a woman in my 60’s with sensitive aging skin, Epicutis saved the day, I’ve been using the product for 2 weeks now and have started to notice a huge difference. My skin is supple, soft, reducing redness, fine lines, and wrinkles. Wow and no breakouts! Makeup goes on smoothly after using the regiment if you choose to even use any! Great products with considerable results ~ loyal customer here!



Catalog # Model Stimulus/Inducer Endpoint Method  Reference
SKI-001 Human Epidermal Keratinocytes (NHEKs) or Human Reconstructed Epidermis (EpiDerm™) TPA/PMA Chemical irritation Cytokine ELISA Glucocorticoid
SKI-002 UVB Photodamage
SKI-003 Sunburn Cells Vitamin C
SKI-004 DNA pyrimidine dimers
SKI-005 Lipid Peroxides
SKI-006 Peripheral Blood Mononuclear Cells (PBMC) anti-CD3/CD28 T-cell activation Th2/Th17-marker ELISA TGF-beta
SKI-007 Human Dermal Microvascular Endothelial Cells (HDMECs) ATP-gS ATP inflammation MTS Viability, Cytokine ELISA Glucocorticoid
SKI-008 anti-microbial peptide (LL-37) Cathelicidin
SKI-009 Nickel sulfate Nickel Allergy
SKI-010 Human Epidermal Keratinocytes (NHEKs) C. acnes, PGN IL-8 Dexamethasone
SKI-011 Human Reconstructed Cornea (EpiOcular™) Dry Eye Viability, MMP9
Dr. Stock and his son Maxwell Stock founded Signum Biosciences Inc., a biotechnology company spun out of Princeton University, whose focus is to develop novel ingredients for both the cosmetic and pharmaceutical space.
By continuing to modify small molecules in order to yield skin benefitting effects, TSC was created. Its ability to repair skin, lower inflammation and many other skin health promoting properties makes it a unique ingredient without comparison
Signum’s corporate partner Rohto Pharmaceutical’s top formulator Masanori Tamura is the developer of Japan’s #1 moisturizer line Hada Labo. Tamura’s high-quality formulation efforts at Rohto attracted to the Signum Team’s attention while he was working in the US. After collaborating, Tamura joined the Signum team as our head formulator and director of Product Development.
Our development of botanical extracts began as an interest in the foods we know to be therapeutic. By studying foods that humans already crave and consume we can make assumptions on why these foods are sought after. Chia seeds are exceptionally powerful and when put through our patented extraction process, yields a novel, proprietary topical oil that improves skin hydration and barrier function unlike any other on the market.
After 20 years of dermatology focused R&D, Epicutis™ is launched using unique, patented ingredients in simple formulations. We have created two products to help maintain skin health rather than trying to address the surface level symptoms of our skin.
After 20 years of dermatology focused R&D, Epicutis™ is launched using unique, patented ingredients in simple formulations. We have created two products to help maintain skin health rather than trying to address the surface level symptoms of our skin.